How to boost your NAD+ levels

Imagine you're trying to fill a bathtub, but you've got three challenges: the faucet isn't running at full pressure, there's a leak in the water supply pipes, and the drain keeps letting water escape. Turning up the faucet alone won't solve your problem—you need a three-part solution to get that perfect bath.

That's exactly the approach we took with one of the most important molecules in your body: NAD+.

The NAD+ bathtub: more than just turning up the faucet

NAD+ is the cellular energy currency that powers everything in your body, from energy production to DNA repair. By age 50, your NAD+ levels are about half of what they were in your 20s. This decline affects virtually every aspect of how you feel and function.

Most supplements take a simplistic approach—they just try to "turn up the faucet" by adding an NAD+ precursor. But just like with our bathtub analogy, that's addressing only one-third of the challenge.

The 3-part strategy for filling your NAD+ bathtub

In your HOP Box, we've included three strategic ingredients that work together to support healthy NAD+ levels in a way none could achieve alone.

1. Nicotinamide riboside (NR): turning up the faucet

NR is one of the most efficient precursors to NAD+. Taking NR is like opening the faucet wider—it provides the raw material needed to make more NAD+.

This is where most supplements stop. But we're just getting started.

2. Trimethylglycine (TMG): fixing the plumbing system

When your body processes NR to make NAD+, it uses up methyl groups—crucial molecules needed for DNA repair, neurotransmitter production, and detoxification. Without addressing this, you might fix one problem while creating another.

That's why we included TMG, a powerful methyl donor, in HOP Box. It's like fixing the leaky pipes in your plumbing system, so water pressure stays strong throughout the house. TMG ensures your NAD+ boost doesn't come at the expense of other vital functions.

3. Apigenin: plugging the drain

Even if you successfully boost NAD+ production, there's another challenge: an enzyme called CD38 constantly breaks it down. CD38 activity increases with age, creating a frustrating situation where you're producing more NAD+ while simultaneously breaking it down faster.

Apigenin, a flavonoid in your HOP Box, helps inhibit CD38 activity. It's like putting a better plug in the bathtub drain, so the water you're adding doesn't simply wash away.

The amplified effect

When these three ingredients work together, something remarkable happens:

• NR efficiently increases NAD+ production (turns up the faucet)
• TMG prevents methyl depletion that might otherwise occur (fixes the pipes)
• Apigenin slows NAD+ breakdown by inhibiting CD38 (plugs the drain)

The result is more sustained NAD+ support than any single ingredient could provide alone. This is what we mean by "amplified effects"—strategic combinations that multiply benefits beyond simple addition.

The research behind the strategy

This synergistic approach isn't just a nice metaphor—it's backed by science:

• Studies show that combining NAD+ precursors with methyl donors can prevent the elevation in homocysteine (a marker of methyl group depletion) that can sometimes occur.
• Research demonstrates that CD38 inhibition significantly increases NAD+ levels in tissues, showing the importance of addressing breakdown and production.
• The latest longevity research increasingly emphasizes the importance of system-wide approaches rather than single-pathway interventions.

Simple but strategic

While your HOP Box is designed for convenience—just one pack, taken twice daily—there's nothing simplistic about its formulation. Each ingredient is selected not only for its individual benefits but for how it works with other compounds to create amplified effects.

The NAD+ support system is just one example of this strategic approach. In future newsletters, we'll explore other synergistic combinations in your HOP Box, from our gut-metabolism connection to our cellular cleanup crew.

The bottom line

The next time you take your HOP Box, remember that you're not just getting the convenience of 19 research-backed ingredients in one simple pack. You're benefiting from carefully orchestrated combinations where the whole truly is greater than the sum of its parts.

That's the science of better together.