Metformin vs. berberine

If you follow longevity news, you’ve likely heard the hullaballoo around the prescription drug metformin. Some people, such as researchers David Sinclair and Nir Barzilai, believe that metformin may have the ability to increase health span or even lifespan.

Metformin: A longevity marvel?!

A medication traditionally used to manage Type 2 Diabetes, metformin has unexpectedly found itself in the spotlight of longevity research. Studies, including the celebrated TRIM trial, have illustrated its capacity to rejuvenate aged cells, potentially delaying age-related diseases.

The drug’s ability to activate AMPK, reduce blood sugar levels, exhibit anti-inflammatory properties, and improve insulin sensitivity positions it as a promising candidate in the fight against aging.

Berberine: A natural challenger

Enter berberine, a natural compound found in plants, emerging as a formidable counterpart to metformin. But how does it stack up in comparison? Let’s explore.

Similarities between berberine and metformin

1. AMPK activation. Both compounds activate AMP-activated protein kinase, maintaining cellular energy balance.
2. Blood sugar control. They contribute to reduced blood sugar levels, vital for metabolic health and longevity.
3. Anti-inflammatory effects. Both exhibit anti-inflammatory properties, combating chronic aging-related inflammation.
4. Potential fat loss. Berberine and metformin have been linked to potential fat loss through various mechanisms, including improved insulin sensitivity.
5. Cardiovascular health. Each has shown promise in promoting cardiovascular health, a critical component of a longer, healthier life.

Advantages of berberine

1. Fewer gastrointestinal side effects. Berberine tends to be gentler on the stomach, with fewer reports of gastrointestinal distress.
2. No prescription needed. Berberine is available over the counter, providing easy and convenient access.
3. No vitamin B12 deficiency. Unlike metformin, berberine does not interfere with B12 absorption, sidestepping potential deficiency issues.
4. Doesn't inhibit muscle growth. For those engaged in resistance training, berberine does not appear to inhibit muscle hypertrophy, a noted concern with metformin.
5. Antioxidant properties. Berberine also boasts antioxidant properties, contributing to its overall health benefits.

Dihydroberberine: The next step in berberine evolution

Building on the strengths of berberine, dihydroberberine (GlucoVantage®) emerges as a more bioavailable and even better-tolerated form.

This means you can achieve the desired effects with lower doses, minimizing any potential for gastrointestinal discomfort. It encapsulates the promise of Berberine while elevating its potential, offering an accessible and potent option in your longevity toolkit.

That’s a (w)rap (battle!)

While metformin’s credentials in the longevity space are impressive, berberine and dihydroberberine present compelling natural alternatives.

And, because we’ve always got your back, we’ve included 100 mg of dihydroberberine in each of our cute little HOP Box packs! Boom! Take that, rap battle! 🎤

HOP to it!