The black box warning on menopause hormone therapy is gone

Something happened on November 10, 2025, that I never thought I'd see in my lifetime.

The FDA removed the black box warning from menopause hormone therapy (MHT), aka hormone replacement therapy.

After 23 years of fear, misinformation, and women being told that the very treatment designed to help them was too dangerous to consider, the agency finally said: we got it wrong.

"This is, in my opinion, one of the greatest mistakes in modern medicine," said FDA Commissioner Dr. Marty Makary. "The demonization of hormone replacement therapy."

The science has been corrected. Estrogen patches are so in demand they're on backorder worldwide. And women are finally being taken seriously. Yay!

The hormone question (and where HOP Box fits in)

Let me be clear: HOP Box is not hormone therapy. It's not a substitute for it, either.

If you're a candidate for MHT and your doctor recommends it, go for it. The black box is gone. The science is clear. For many women, hormones are life-changing.

But here's the thing: whether you're on hormones or not, your cells and organs are still adjusting. To life without the estrogen levels they're used to. To the wild fluctuations of perimenopause. To replaced hormones that help but don't erase the transition entirely.

Either way, they need support. That's what HOP Box does.

• Tributyrin for gut barrier support (94% of perimenopausal women report digestive issues).
• Dihydroberberine for the blood sugar creep that sneaks up at midlife. 
• Vitamin D3 with K2, plus magnesium glycinate, because bone loss starts in perimenopause, not menopause. 
• Astaxanthin, hyaluronic acid, and spermidine for skin that's losing collagen faster than you'd like.

Nothing flashy. Just foundational support for one of the biggest biological shifts of your life.

The bottom line

This is a historic moment for women's health. But even with the black box gone, the fundamentals haven't changed: your cells need support, your gut needs protection, and your body needs you in its corner.

We’ll be right there with you.

Now, HOP to it!

Dr. Amy Killen & the HOP Team