Why tributyrin is your gut’s new best friend

In the ever-evolving world of gut health, we're always looking for the most effective ingredients to help you thrive. That's why when formulating the Equalizer pill in your HOP Box, we didn't just stop at probiotics or prebiotics—we went straight for the powerhouse postbiotic: tributyrin.

Beyond pre and probiotics: cutting out the middleman

You've likely heard about:

• Probiotics: Live beneficial bacteria you consume
• Prebiotics: Food for those beneficial bacteria

But let's talk about postbiotics—the compounds that beneficial gut bacteria produce after they've fermented prebiotics. These are the actual beneficial end products your body uses.

With tributyrin (found in our NewBiome® compound), we're essentially cutting out the middleman and delivering the good stuff directly. Think of it this way:

🙏 Prebiotics + probiotics = Hope that your gut environment will eventually produce beneficial postbiotics

🎯 Tributyrin = Direct delivery of those beneficial compounds without waiting or wondering

The science: why tributyrin is special

Tributyrin is a triglyceride molecule consisting of three butyrate molecules attached to a glycerol backbone. When it reaches your intestines, it breaks down and releases butyrate—a short-chain fatty acid that's absolutely crucial for gut health.

Here's what makes tributyrin uniquely effective:

1. Superior delivery. Regular butyrate supplements are rapidly absorbed in the upper GI tract before reaching the colon where they're needed most. Tributyrin, however, remains stable through the stomach and small intestine, delivering butyrate directly to the colon where it has the most benefit.
   
   
2. Sustained release. Unlike other forms of butyrate that are quickly metabolized, tributyrin provides a slow, sustained release of butyrate throughout the colon.
   
   
3. Higher bioavailability. Research shows tributyrin delivers 3-4 times more butyrate to the colon than traditional butyrate supplements.

The benefits: what this means for you

The direct delivery of butyrate through tributyrin offers remarkable benefits:

• Strengthens gut barrier function. Butyrate reinforces the tight junctions between cells in your intestinal lining, reducing leaky gut and keeping unwanted particles from entering your bloodstream.
  
  
• Reduces inflammation. Butyrate activates anti-inflammatory pathways, helping to calm systemic inflammation—a root cause of accelerated aging.
  
  
• Supports immune balance. About 70% of your immune system resides in your gut. Butyrate helps regulate immune responses, reducing inappropriate reactions while maintaining proper defense.
  
  
• Improves insulin sensitivity. Research shows butyrate helps improve glucose metabolism and insulin sensitivity—key factors in metabolic health and longevity.
  
  
• Protects against oxidative stress. Butyrate upregulates antioxidant enzymes, helping combat the cellular damage caused by free radicals.

Why we chose NewBiome® tributyrin

Not all tributyrin supplements are created equal. The NewBiome® tributyrin in our Equalizer pill is:

• Pharmaceutical-grade, with 99% purity
• Micro-encapsulated for optimal delivery
• Clinically studied for efficacy
• Tasteless and odorless (unlike regular butyrate, which has a strong, unpleasant smell)

At 500mg per serving, we've included the research-backed dose shown to significantly benefit gut health and beyond.

The bottom line

With tributyrin, we're taking the most direct path to gut health—giving your body the beneficial compounds it needs without relying on the complex and often unpredictable bacterial fermentation process.

In a world where gut health is increasingly recognized as fundamental to overall well-being and longevity, tributyrin represents a sophisticated, science-backed approach to supporting your microbiome and, by extension, your entire body.