Taken twice daily, each HOP pill pack contains five capsules filled with 19 research-backed ingredients that combat the root causes of aging at the cellular level.
Fisetin, quercetin, and apigenin belong to a group of plant-based chemicals called flavonoids. These ingredients are most known for their ability to clear senescent cells, reduce inflammation, and bolster NAD levels. Oh, and they may promote a smooth mood and even smoother skin.
Quercetin, fisetin, and apigenin are all known for their potent anti-inflammatory properties and ability to reduce oxidative stress via several different pathways. Since inflammation is one of the root causes of most diseases (including aging), we think this is a pretty big deal.
Quercetin and apigenin also promote healthier NAD+ levels, which naturally decline as we age. NAD+ is a critical coenzyme in our bodies that is necessary for producing cellular energy and repairing DNA. Quercetin and apigenin work to prevent the breakdown of NAD+ by the enzyme CD38, thus protecting these fundamental metabolic processes.
In addition, studies have shown that fisetin and quercetin can clear senescent cells (“the hecklers”) to reduce inflammation and improve stem cell activity. This promising potential to eliminate those nasty senescent cells has a LOT of people talking about these two flavonoids.
Some other fun facts about our favorite flavonoids:
Curcumin is one of the most-studied and longest-loved longevity-promoting ingredients because of its strong anti-inflammatory and antioxidant properties. However, in the past, curcumin’s poor bioavailability made it challenging to get high enough doses through oral supplementation. Luckily, CurcuPrime® by NNB has solved that problem, giving you the same benefits of curcumin but with better absorption and bioactivity.
Do you ever feel like Mother Nature is playing tricks on us, secretly laughing behind those weeping willows? We think that curcumin may be one of her favorite tricks.
Curcumin is a bright yellow polyphenol derived from turmeric root. It has been used for hundreds of years and possesses multiple alleged superpowers, including antioxidant, anti-inflammatory, anti-cancer, anti-microbial, and anti-pain properties.
In humans, curcumin has been shown to improve memory and brain function, improve lipids (including LDL oxidation), and reduce blood sugars.
In addition, multiple animal models have shown that curcumin can extend lifespan by as much as 26%! We can likely credit this impressive increase to curcumin’s potent antioxidant, anti-inflammatory, and blood sugar regulation abilities, its promotion of longer telomeres, and its elimination of senescent cells. Whoa!
So, how is any of this a trick? It sounds pretty great, right?
It’s a “trick” because traditional curcumin has low bioavailability when taken orally because of its rapid breakdown, which means very little of it gets or stays in the body.
Luckily, CurcuPrime® (tetrahydrocurcumin), the branded ingredient in HOP Box, resolves the poor bioavailability of traditional curcumin by offering a longer-lasting, more active form of this long-loved ingredient.
And, if you’re wondering which of the Downfalls of Aging curcumin directly supports, the answer is ALL of them. Isn’t Mother Nature the coolest!
Astaxanthin is the Queen of antioxidants and may protect the eyes and skin against UV damage, slow brain aging, and promote a healthier heart, stronger muscles, and less painful joints.
It wouldn’t be a stretch to call astaxanthin the Queen of the Antioxidants, given that this particular nutrient is 500 times stronger than vitamin E and 6000 times more potent than vitamin C at subduing oxidative stress.
Found naturally in microalgae, yeast, and some types of fish, astaxanthin can be tricky to incorporate into your diet in sufficient amounts. However, supplementing with this antioxidant is well worth the effort, since she has her Queenly fingers in many pies when it comes to slowing aging and bolstering beauty.
Astaxanthin is probably most known for its benefits to the eyes, where it’s been shown to protect against UV damage, decrease eye strain, and improve visual acuity in its users.
Similarly, astaxanthin is well-loved for its skin effects. Studies have shown that this antioxidant protects the skin from UV damage and promotes the repair of damaged and aging skin, helping with everything from skin hydration and elasticity to age spots and wrinkles.
A recent study in adults also found that supplementing with astaxanthin daily may slow brain aging and promote improvements in memory.
Finally, astaxanthin may improve cardiovascular and immune health while promoting stronger muscles and less painful joints.
So, yeah. Astaxanthin is a total Queen, and we’re excited to feature it in our all-star HOP Box line-up!
The GlucoVantage® inside HOP Box is five times more bioavailable and lasts twice as long as traditional berberine, which means more of berberine’s “secret sauce” gets to the cells. Studies have shown that berberine promotes reductions in blood sugar, insulin, and fat storage due to its activation of the longevity-promoting AMPK cellular pathway.
Have you ever had a secret that was SO good you almost didn’t want to share it? Well, berberine might just be longevity medicine’s best-kept secret, and we want to yell it from the rooftops.
Berberine is naturally found in a variety of plants and is best known for its ability to reduce blood glucose (sugar) and insulin levels.
Chronically elevated blood glucose is an indicator of cells’ inability to take in and use energy effectively and a major cause of metabolic syndrome and inflammation in the body.
Put another way, high blood sugar, even in non-diabetics, makes us age faster!
Berberine not only improves how our cells use glucose but has also been shown to shuttle glucose to muscles instead of fat cells, which may assist with fat loss over time.
Berberine’s fat-burning, sugar-lowering properties stem from its ability to activate a cellular enzyme called AMPK. We can also activate AMPK through exercise and caloric restriction, two other longevity-promoting practices known to improve metabolic health.
This effect is a big deal since more than 70% of Americans are pre-diabetic or diabetic, and more than 85% of us are metabolically unhealthy.
Traditional berberine, although fabulous, is poorly absorbed and often causes gastrointestinal upset (not so fabulous!). However, the dihydroberberine (GlucoVantage®) found in HOP Box is five times more bioavailable than traditional berberine, lasts twice as long in the blood, and doesn’t cause the same stomach upset.
See, we told you this was a secret worth telling!
Curcumin is one of the most-studied and longest-loved longevity-promoting ingredients because of its strong anti-inflammatory and antioxidant properties. However, in the past, curcumin’s poor bioavailability made it challenging to get high enough doses through oral supplementation. Luckily, CurcuPrime® by NNB has solved that problem, giving you the same benefits of curcumin but with better absorption and bioactivity.
Do you ever feel like Mother Nature is playing tricks on us, secretly laughing behind those weeping willows? We think that curcumin may be one of her favorite tricks.
Curcumin is a bright yellow polyphenol derived from turmeric root. It has been used for hundreds of years and possesses multiple alleged superpowers, including antioxidant, anti-inflammatory, anti-cancer, anti-microbial, and anti-pain properties.
In humans, curcumin has been shown to improve memory and brain function, improve lipids (including LDL oxidation), and reduce blood sugars.
In addition, multiple animal models have shown that curcumin can extend lifespan by as much as 26%! We can likely credit this impressive increase to curcumin’s potent antioxidant, anti-inflammatory, and blood sugar regulation abilities, its promotion of longer telomeres, and its elimination of senescent cells. Whoa!
So, how is any of this a trick? It sounds pretty great, right?
It’s a “trick” because traditional curcumin has low bioavailability when taken orally because of its rapid breakdown, which means very little of it gets or stays in the body.
Luckily, CurcuPrime® (tetrahydrocurcumin), the branded ingredient in HOP Box, resolves the poor bioavailability of traditional curcumin by offering a longer-lasting, more active form of this long-loved ingredient.
And, if you’re wondering which of the Downfalls of Aging curcumin directly supports, the answer is ALL of them. Isn’t Mother Nature the coolest!
These B vitamins and methyl donors promote healthy brains and blood vessels by acting as methyl group “banks” for thousands of intracellular processes.
If you’re a little put out by this alphabet soup of nutrients, we don’t blame you. It’s a mouthful of methylation donors if we’ve ever seen one!
Vitamins B2, B6, B12, 5-MTHF (the active form of folate), and TMG (trimethylglycine) do many things, but some of their most important longevity benefits stem from their ability to act as methyl donors.
What does this mean?
Have you ever seen those “Take a Penny, Leave a Penny” bowls at the gas station? Where you can take a penny to complete your transaction, or you can leave a penny to help the next person? That penny is kind of like a methyl group.
In every cell in the body, methyl groups are transferred back and forth between DNA strands, proteins, enzymes, and hormones to regulate everything from your mood and energy levels to how quickly your blood vessels fill with plaque and how fast you can get rid of toxins. Methylation helps repair DNA, protects against cancer, and keeps your immune system healthy.
But, to have enough methyl groups for these many processes, somebody has to “leave a penny,” which is where our B vitamins, 5-MTHF and TMG come in.
These vitamins are essential for helping to reduce homocysteine levels in the blood, which can significantly reduce the risk of cardiovascular disease. And they are so necessary for optimal brain function that low levels can be associated with actual brain shrinking!
Oh, and did we mention that your body doesn’t store B vitamins, so you need to frequently ingest them in food or as nutritional supplements?
