Some proteins grow into it, but she’s always been a Misfit. From the moment she was first folded improperly by a bunch of incompetents, she’s been unlike everyone else. When the other proteins were sent out into the world, Protein Misfit was thrown into a corner. She was told she wasn’t appropriate for “polite protein society” since she looks weird and doesn’t really have a function. So, she sits and broods and gets angry.
Luckily for her, as time goes by, more and more Misfits are getting made by the cell. They all get thrown into her corner. Sometimes, they have dance parties and form these little Misfit mosh pits – that really makes the cell mad. Occasionally, a few of the Misfits get thrown out of the cell, but there are so many of them these days that the cell can’t keep up, which is just fine with her.
What is happening inside my body?
This is the story of loss of proteostasis, which means loss of protein balance. Protein imbalance can occur for a variety of reasons. Sometimes, the instructions for forming amino acid chains, which come from DNA and then mRNA, are incorrect.
This is the story of loss of proteostasis, which means loss of protein balance. Protein imbalance can occur for a variety of reasons. Sometimes, the instructions for forming amino acid chains, which come from DNA and then mRNA, are incorrect.
Other times, the proteins that facilitate the folding of the amino acid chains, the chaperones, aren’t working properly. Sometimes the folded proteins are stickier than they should be, resulting in protein aggregates. Other times, the protein degradation machinery within the cells malfunctions, leading to the build-up of proteins.
Other times, the proteins that facilitate the folding of the amino acid chains, the chaperones, aren’t working properly. Sometimes the folded proteins are stickier than they should be, resulting in protein aggregates. Other times, the protein degradation machinery within the cells malfunctions, leading to the build-up of proteins.
Whatever the underlying cause, loss of proteostasis is one of the nine hallmarks of aging and is responsible, in part, for many age-related diseases, including Alzheimer’s disease.
Whatever the underlying cause, loss of proteostasis is one of the nine hallmarks of aging and is responsible, in part, for many age-related diseases, including Alzheimer’s disease.
Why this matters to you
Whatever the underlying cause, loss of proteostasis is one of the nine hallmarks of aging and is responsible, in part, for many age-related diseases, including Alzheimer’s disease.
How the HOP Box Helps: Ingredients such as Berberine, Quercetin, and Curcumin reduce inflammation, which can help protect the essential proteins and prevent Protein Misfits.
